*This collection was prepared by Zhiping Yu, PhD, RD, LDN, Editorial Science Fellow at The Journal of Nutrition.
This featured collection highlights seven recent studies published in The Journal of Nutrition that collectively examine how behavioral, dietary, physiological, and environmental factors influence weight management and metabolic health, while also addressing tools and mechanisms to improve monitoring, intervention effectiveness, and health outcomes related to obesity. References are listed in the end.
The STRIPED Dietary Supplement Label Explorer: A Tool to Identify Supplements Sold with Weight-Loss, Muscle-Building, and Cleanse/Detox Claims
This study developed a novel, publicly available tool using the Dietary Supplement Label Database Application Programming Interface (DSLD API) to classify dietary supplement labels with weight loss, muscle building, and cleanse/detox claims. Systematic heuristics outperformed deep learning for certain classifications but required more development effort. The tool enables scalable monitoring of potentially misleading supplement claims, supporting research and consumer protection.
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Weight-Reducing Dietary Intervention Increases the Ability of Hyperinsulinemia to Suppress Serum Ghrelin Concentration in Individuals with Obesity
This study found that individuals with obesity exhibit impaired ghrelin suppression in response to insulin, which is improved following a 12-week weight-reducing dietary intervention. The novelty lies in demonstrating that weight loss restores insulin-mediated ghrelin regulation, suggesting improved appetite control mechanisms. These findings have important implications for obesity treatment by highlighting a physiological pathway through which weight loss may enhance satiety.
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Daily Dietary Protein Distribution Does Not Influence Changes in Body Composition During Weight Loss in Women of Reproductive Years with Overweight or Obesity: A Randomized Controlled Trial
This randomized controlled study found that protein distribution (even vs. skewed across meals) did not significantly influence changes in body composition during weight loss in women, as all participants experienced similar reductions in body weight, fat mass, and fat-free mass. The novelty lies in directly testing protein timing patterns under controlled feeding conditions, showing no added benefit of even distribution. These findings suggest that total protein intake, rather than distribution, may be more relevant for body composition during weight loss.
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Cafeteria Diet-Induced Obesity Alters Uterine Function by Disrupting Insulin and Sex Steroid Actions in Rats
This study found that cafeteria diet–induced obesity disrupts uterine function in rats by reducing ovarian hormones and increasing oxidative stress, leading to altered expression of key molecular regulators. The novelty lies in linking diet-induced obesity to hormonal and oxidative changes that impair uterine physiology. These findings highlight potential mechanisms by which obesity may negatively affect female reproductive health.
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Can Probiotics Influence Adaptive Thermogenesis Induced by Continuous Energy Restriction after a 12-Week Intervention in Adult Males Living with Obesity? A Secondary Analysis of a Randomized Clinical Trial (Sao Paulo Clinical Study of Obesity and Intestinal Microbiota)
This study found that probiotic supplementation did not attenuate adaptive thermogenesis during continuous energy restriction in males with obesity, as both groups showed similar reductions in resting energy expenditure and body composition. The novelty lies in evaluating the role of probiotics in metabolic adaptation during weight loss using a randomized controlled design. These findings suggest limited efficacy of probiotics in modifying energy expenditure adaptations, with implications for weight loss strategies.
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The Effect of Habitual Sleep Duration on Weight Loss during a Behavioral Weight Loss Intervention in a Mediterranean Population
This study found that habitual long sleep duration (>8 h) is associated with reduced weight loss, lower likelihood of achieving clinically meaningful weight loss, and higher attrition during a behavioral intervention. The novelty lies in using a large, longitudinal cohort to clarify the role of sleep duration in weight loss outcomes. These findings suggest that sleep patterns, particularly long sleep, may influence intervention success and should be considered in weight management strategies.
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The Role of Meal Timing in Appetitive Responses to Acute Exercise in Adolescents with and without Obesity: A Systematic Review and Meta-Analysis
This review found consistent evidence that the timing of meals after acute exercise does not significantly affect energy intake overall, although effects differ by weight status, with some modulation observed in lean youth. The authors conclude that post-exercise meal timing has limited universal impact on appetite but may be phenotype-specific. Future research should explore mechanisms and individual variability, with applications in tailoring exercise–nutrition strategies to optimize appetite regulation.
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References:
- Vitagliano JA, Kavanaugh JR, Gorges B, et al. The STRIPED Dietary Supplement Label Explorer: A Tool to Identify Supplements Sold with Weight-Loss, Muscle-Building, and Cleanse/Detox Claims. J Nutr. 2025;155(4):1258-1267.
- Karczewska-Kupczewska M, Stefanowicz M, Nikołajuk A, Strączkowski M. Weight-Reducing Dietary Intervention Increases the Ability of Hyperinsulinemia to Suppress Serum Ghrelin Concentration in Individuals with Obesity. J Nutr. 2024;154(5):1631-1639.
- De Leon A, Roemmich JN, Casperson SL. Daily Dietary Protein Distribution Does Not Influence Changes in Body Composition During Weight Loss in Women of Reproductive Years with Overweight or Obesity: A Randomized Controlled Trial. J Nutr. 2024;154(4):1347-1355.
- Srinivasan D, Raghavendhira H, Khan MZI, Kannan S, Bhaskaran RS. Cafeteria Diet-Induced Obesity Alters Uterine Function by Disrupting Insulin and Sex Steroid Actions in Rats. J Nutr. 2025;155(6):1859-1869.
- Ferracini CBF, Guazzelli Marques C, Nakamoto FP, et al. Can Probiotics Influence Adaptive Thermogenesis Induced by Continuous Energy Restriction after a 12-Week Intervention in Adult Males Living with Obesity? A Secondary Analysis of a Randomized Clinical Trial (São Paulo Clinical Study of Obesity and Intestinal Microbiota). J Nutr. 2025;155(11):4043-4059.
- Rodríguez-Martín M, Szczerbinski L, Garaulet M, Dashti HS. The Effect of Habitual Sleep Duration on Weight Loss during a Behavioral Weight Loss Intervention in a Mediterranean Population. J Nutr. 2025;155(11):4060-4064.
- Moore H, Fillon A, Beaulieu K, et al. The Role of Meal Timing in Appetitive Responses to Acute Exercise in Adolescents with and without Obesity: A Systematic Review and Meta-Analysis. J Nutr. 2025;155(3):719-728.












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