A recent study published in The Journal of Nutrition found that participants with abnormal blood lipid profiles that consumed 17.28 grams or more of dietary fiber per day had metabolic patterns similar to those of healthy individuals.

Dyslipidemia, characterized by nonoptimal levels of lipids circulating in the blood, is associated with increased risk of metabolic disorders such as cardiovascular disease, type 2 diabetes, and hypertension. Dietary factors have a significant impact on dyslipidemia and treatment guidelines emphasize a healthy dietary pattern as the first line of therapy. However, research remains unclear as to which dietary approach is most efficacious.  These inconsistencies are often attributed to metabolic difference among those with dyslipidemia.  Metabolomics, a comprehensive analysis of metabolites in biological samples, is an effective tool for monitoring the metabolic state and has great potential for identifying nutritional factors that differ based on metabolite patterns.

To identify metabolic differences related to dietary characteristics among patients with dyslipidemia, Kim (Hannam University, Republic of Korea) and colleagues applied nontargeted metabolomics technology to discover nutritional factors that differ based on patients’ metabolite patterns.  The blood metabolomes of dyslipidemia patients were compared to those of health control patients.  Traits that differed in terms of the patients’ metabolite patterns were investigated.  The goal was to discover metabolomic biomarkers and associated nutritional variables that could be used to monitor the metabolic status of dyslipidemia patients.

Participants with dyslipidemia were divided into 2 groups based on whether they were or were not in a similar metabolic state as the controls. Significant correlations were observed between 4 metabolites and fiber intake. Furthermore, dietary fiber intake was significantly higher in dyslipidemia participants whose metabolic state was similar to those of the control vs. the dissimilar group.

Study results revealed that participants with dyslipidemia who consumed 17.28 grams of dietary fiber per day maintained similar metabolic patterns to healthy individuals with substantial effects on changes in the concentrations of 4 metabolites. This study presented evidence for the benefits of dietary fiber intake in patients with dyslipidemia. In addition, the possible mechanisms associated with the significant biochemical variables observed in this study may provide a basis for understanding the metabolism of dyslipidemia.


Han Y, Jang K, Kim U, Huang X, Kim M. The Possible Effect of Dietary Fiber Intake on the Metabolic Patterns of Dyslipidemia Subjects: Cross-Sectional Research Using Nontargeted Metabolomics. The Journal of Nutrition, Volume 153, Issue 9, September 2023, Pages 2552-2560, doi.org/10.1016/j.tjnut.2023.07.014.

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