About

ChromaDex Corp. is a global authority on nicotinamide adenine dinucleotide (NAD+) with a focus on the science of healthy aging and a leading member of ASN’s Sustaining Partners. The ChromaDex team, inclusive of world-renowned scientists, works with independent investigators from esteemed universities and research institutions around the globe to uncover the full potential of NAD+. A vital coenzyme found in every cell of the human body, NAD+ declines with age and exposure to other everyday stressors, making NAD+ a contributor to age-related changes in health and vitality. ChromaDex is the innovator behind its clinically proven flagship ingredient, Niagen®, patented nicotinamide riboside (NR), one of the most efficient and superior-quality NAD+ boosters available.

Interested in building collaborations within these functional areas:

• The Role of NAD+ in Healthy Aging and Age-Related Disease
• Age-Related Declines In:
  • Cognition
  • Exercise Performance
  • Quality of Life/Sleep
  • Sensory (Vision, Hearing, Touch) Function
  • Biological Age
  • Women’s Health (Fertility, Menopause
• We are also interested in collaborating on opportunities to educate healthcare practitioners and enhance diversity, equity, and inclusion in the industry and research communities.

Support & Funding Opportunities:

• When you are considering what ingredient to study to support nutrition advancements, please consider NAD+ precursors. Some NAD+ precursors including various forms of Vitamin B3 are available as dietary supplements, and others that are under development. NAD+ is essential to all cells, and there are many questions about the benefits and drawbacks from supplementation. There are many opportunities related to how NAD+ contributes to optimal health, diseases (beyond pellagra), and reducing the risk of various illnesses.
• ChromaDex is the main owner and licensee of over 50 patents related to NR, and in collaboration with our strategic partners, manufactures both NR as the ingredient Niagen® and the consumer dietary supplement product, Tru Niagen®, to the highest quality (NSF Certified for Sport®; Quality Page) and scientific standards (over 30 human clinical studies and over 300 published scientific studies). For over 20 years, ChromaDex has been an industry leader in analytical methods, reference standards, and proprietary ingredients.
• ChromaDex was honored with the “2019 Best of the Industry: Ingredient Supplier” award from Nutritional Outlook for our efforts to set the industry Gold Standard for excellence in commercial science and safety.
• The ChromaDex External Research Program (CERP) is an essential component of ChromaDex’s R&D Program. We value and encourage strong scientific rigor behind our products, and our relationships with academic and government institutions help make this happen. Through CERP, we are the leading supplier of patented NR to the research community, with nearly 50% of all NR peer-reviewed publications using our material, worldwide. Since 2013, we have developed over 275 material transfer agreements with more than 190 institutions in more than 30+ countries to advance the scientific exploration of NR and other ChromaDex compounds. We provide ChromaDex bulk and/or clinical material (including placebo), for exceptional preclinical and clinical research projects that are selected from a continuous pool of applicants. More than 90% of our studies are investigator-driven and third-party funded. These collaborations have resulted in over 150+ peer-reviewed publications, including 30+ clinical publications, and more than 70% of ongoing or completed clinical NR trials registered on clinicaltrials.gov are using or have used our materials. For ChromaDex’s outstanding efforts to advance the science of NAD+, CERP was honored by European NutraIngredients in the “Nutrition Research Project” category for developing the science behind Niagen® and has been featured in top-tier publications such as Forbes. 3..
• Niagen® has both new dietary ingredient (NDI) and generally recognized as safe (GRAS) notifications from the US-FDA recognizing it is safe for both dietary and food ingredient needs. Our product has further been reviewed by the European Food Safety Authority (EFSA), Health Canada, the Therapeutic Goods Administration of Australia (TGA), and the Ministry of Agriculture in Turkey allowing for its use in these markets. Niagen® is also approved for use in medical foods in Brazil and New Zealand. We are the only NR product that has obtained any of these safety reviews.
• Every lot of Niagen® and Tru Niagen® is tested for potency, safety, and purity, and certificates of analysis are readily available so consumers can trace their products directly to our lab.
  • All batches are tested to ensure compliance to specifications and label claims, including potency through end of shelf life.
  • A total of 22 tests (internal and third-party) are conducted in the testing and release of Niagen products, including the testing of the raw Niagen ingredient.
  • ChromaDex laboratories are ISO/IEC 17025:2017 accredited.
  • All manufacturing facilities are visited and inspected frequently by our internal inspectors and third-party certifiers including NSF, Alkemist Labs, Star-K (Kosher), and IFANCA (Halal).
• As you determine which NAD+ precursor that you will use for your future studies, please keep the following in mind about Niagen NR:
  • The stability of NR-Cl, depending on the form, is a major concern. ChromaDex’s crystalline form is highly stable as a powder. Other providers may sell an amorphous form which is highly unstable, and quickly gelatinizes when exposed to air, resulting in degradation.
  • Isomeric Purity. Our Niagen® is evaluated for the beta-NR conformation to ensure it is the bioactive form. If the NR-Cl is a mixture of alpha- and beta-NR, the efficacy would be reduced, and little is known if the alpha-NR conformation would inhibit the NAD+ biochemical pathway.
  • Since Niagen® has been reviewed and received safety notifications for dietary and food ingredients, we understand the process and composition of the finished ingredient material. There is little known about the potential contaminants (by-products, solvents, impurities) in third-party sourced NR-Cl, which could impact study results and reproducibility.
• ChromaDex also maintains a Reference Standards & Services business that provides natural products, phytochemical, and botanical reference materials. These standards are used by food companies, supplement firms, testing laboratories, and researchers to confirm the quality and accuracy of their commercial products and research materials. More information is available at: https://standards.chromadex.com/.

Career Support:

• At ChromaDex, we are always looking for great talent in the areas of research & development, analytical method development, regulatory affairs, scientific affairs, and quality assurance/control. We are always open to hearing from researchers, practitioners, post-docs, and students. We have several team members with extensive experience in both academia and industry who can provide career guidance and advice.
• If you are interested in co-oping or interning through our R&D, Reference Standards, or Quality teams, please send an email to internships@chromadex.com.
• Please contact us at HR@chromadex.com to learn about additional career opportunities.

Sustainability Support and Expertise:

• ChromaDex is interested in sustainable processes. We would like to partner and develop relationships with investigators exploring improving sustainability in the dietary supplement and reference standards space.
• Our innovation directives include developing and implementing sustainable processes and reducing our carbon footprint across the organization. Sustainable analytics and processes (such as using supercritical fluid/green chemistry technologies) are being evaluated to replace outdated and hazardous processes. We would be so interested in collaborating with others trending in the same direction – focusing on the three P’s for sustainability – people, planet and products. Contact nick.mitchell@chromadex.com.

Regulatory Insights and Expertise:

• ChromaDex has spent several years supporting and defending inventorship and the academic institutions where the work is performed. We encourage investigators to engage their institutions’ IP teams early to determine the patentability of innovations and prevent obstruction of IP efforts. We encourage investigators to expand their research portfolio to include IP protection.
• We have extensive experience assisting investigators with their investigational new drug (IND) filings related to research on nicotinamide riboside.
• We have extensive experience bringing novel food and dietary supplement ingredients to market in the US and other countries.
• We have extensive expertise in analytical chemistry, synthetic chemistry, and dietary supplements.

Additional Information:

• ChromaDex’s Tru Niagen Healthcare Practitioner website provides access to HCP-specific webinars and modules with registration. Please visit and register at: https://pro.truniagen.com/.
• ChromaDex’s New YouTube Channel features investigator interviews from CERP’s 10th Anniversary: CERP 10 for 10 Series: https://www.youtube.com/@ChromaDex.